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Skin Elasticity - This abstract will get you interested in our new anti-aging beauty product section.
In vivo tretinoin-induced changes in skin mechanical properties.
Br J Dermatol 1990 Apr;122(4):525-9 (ISSN: 0007-0963)
Berardesca E; Gabba P; Farinelli N; Borroni G; Rabbiosi G
Department of Dermatology, University of Pavia, Italy.
Topical tretinoin has been reported as having anti-aging effects on photodamaged
skin. The purpose of this study was to evaluate tretinoin-induced changes in
the mechanical properties of the skin of 18 patients (aged 39 +/- 8 years) after
4 months of treatment with topical 0.05% tretinoin on one forearm and a placebo
base cream on the other. The biomechanical skin parameters investigated were
elasticity, extensibility and hysteresis and data were normalized for skin thickness.
A slight but non-significant increase of skin elasticity was detected in the
tretinoin-treated sites using low-stressing forces (1.2 X 10(4) Nm-2) and at
higher loads (3.8 X 10(4) Nm-2), the increase in skin elasticity was significant
(P less than 0.01). This improved skin elasticity was dependent on the increased
collagen resulting from topical tretinoin and the replacement of elastotic material.
However, topical tretinoin treatment did not improve the responses mediated
by elastic fibres.
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