     
       |
| |
Iron in the brain - this abstract may entice you to consider Chelation Therapy for anti-aging.
Modulation of age-related alterations of iron, ferritin, and
lipid peroxidation in rat brain synaptosomes.
J Nutr Health Aging 1998;2(3):133-7 (ISSN: 1279-7707)
Choi JH; Kim DW; Yu B
Department of Food and Life Science, Pukyong National University, Pusan, Korea.
Oxidative stress, as indicated by increases in lipid peroxidation, is generally
found to increase with age. Also found in various tissues of aged organisms,
including the brain, is the accumulation of iron, a pro-oxidant transition metal.
In this study, iron content and ferritin levels were measured in the synaptosomes
isolated from the frontal cortices of aged male Fischer 344 rats. Age-related
changes in lipid peroxide and the peroxidizability of synaptosomal fatty acids
were also studied in addition to the anti-aging effect of dietary restriction
(DR) (60% food intake of ad libitum (AL) fed animals) on the modulation of age-related
iron status and lipid peroxidation. When comparing the two dietary groups for
the age-related production of reactive oxygen species (ROS), DR was shown to
effectively suppress the amount of age-related ROS in the brain synaptosomes
of these rats. Increases in lipid peroxide and accumulations of total iron and
ferritin in brain synaptosomes of DR rats were also shown to be significantly
lower than those of AL rats. Increased lipid peroxide and accumulated iron overload
were effectively attenuated by DR, and the modulation of synaptosomal iron status
was consistent with previous findings on the anti-aging action of DR.
|
| |
|
CopyManager Administration Interface
|
